Since the inception of the Falcon sports program Aquinas has maintained a consistent level of success, in particular in boys' basketball, football, boys' soccer, and baseball teams. In the summer of 2017 Aquinas was chosen as an official Nike school which allows for the outfitting of the Falcon athletic teams exclusively in Nike apparel. Aquinas athletic teams have won over 120 league championships, 9 CIF championships, and 3 state championships.
- Football – 1958, 1960, 1962, 1964, 1968, 1979, 1981, 2005, 2007, 2008, 2009, 2010, 2016, 2017, 2018, 2019, 2021
- CIF Champions 2000, 2005, 2017, 2019, 2021
- CIF Runner-Up 2016
- State Champions 2005
- State Runner-Up 2019, 2021
- State South Region Champions 2019, 2021
- State South Region Runner-Up 2017
- Girls' volleyball – 1999, 2000, 2012, 2013
- Girls' tennis – 1982, 1983, 1984, 2004, 2005, 2006, 2011, 2015, 2016, 2017, 2019
- Girls' cross country - 2009, 2010
- Boys' basketball – 1960, 1962, 1963, 1964, 1966, 1968, 1969, 1970, 1971, 1972, 1973, 1980, 1983, 1984, 1988, 2008, 2009, 2010, 2020, 2021
- CIF Champions 1973, 2021
- CIF Runner-Up 1968, 1969, 2020
- CIF State Regional Champions 2021
- CIF State Champions 2021*
- Girls' basketball – 1983, 1992, 1993, 2001, 2014, 2015, 2016, 2017, 2018
- Boys' soccer – 1982, 1983, 1986, 1988, 1989, 1993, 1995, 1996, 1997, 1998, 1999, 2018, 2021, 2022
- Girls' soccer – 1990
- Wrestling – 1979, 1984, 1985, 1986
- Baseball – 1959, 1963, 1964, 1965, 1966, 1968, 1969, 1970, 1979, 1980, 1981, 1982, 1983, 1984, 1985, 1986, 1987, 1988, 1990, 1997, 2021, 2022
- Softball – 1976, 1983, 1985, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2017, 2018, 2019, 2020*, 2021, 2022
- CIF Champions 2013
- State Champions 2013
- Golf – 1983, 1984, 2000, 2009
- Boys' track – 1958, 1988, 2003, 2004, 2005, 2022
- Girls' track – 2003, 2004
- Boys Tennis - 2021
- Boys Swim - 2021
